Falcao's second hat-trick in La Liga came on 21 January 2012, when he led his team to a 4–0 victory against Real Sociedad at the Anoeta Stadium.
On 16 February, Falcao scored twice and assisted a goal in an away game against Lazio to progress to the round of 16 in the Europa League.
Falcao began his career at Lanceros Boyacá, before moving to Argentinian club River Plate where he won the 2007–08 Clausura tournament.
Falcao became their all-time top goalscorer in international club competitions and set the record for most goals (17) in a European campaign.
He also became the first Colombian to receive the Portuguese Golden Ball award.
In the 2010–11 season, Porto won the league title in round 25 of the league against rivals and defending champions Benfica at the Estádio da Luz.
Falcao played a key role in that match, winning his team a penalty when the match was tied at 1–1; the penalty was scored by teammate Hulk.
He went on to score three goals in as many games, making him one of the few to score four goals in the first four matchdays in the Portuguese league.
On 15 September, he made his UEFA Champions League debut in a 1–0 away defeat against Chelsea.
He further added to his position as top scorer in the competition by scoring four goals in the semi-final first leg against Villarreal, a game which finished 5–1 in favour of Porto.
In the Europa League final against domestic rivals Braga, Falcao scored the only goal of the game with a header after a cross from Fredy Guarín, giving the title to Porto.
He represented the country at the 20 Copa América, but missed the 2014 FIFA World Cup through injury.